Air Canada has suspended all flights to Venezuela, saying it "can no longer ensure the safety of its operation."
The airline posted the notice on its website Monday stating all flights are off "until further notice."
Its last flights departed Toronto on Saturday and Caracas on Sunday.
"Air Canada will continue to monitor the situation and will evaluate the re-introduction of flights with the objective of resuming operations on the route once Air Canada is satisfied that the situation in Venezuela has stabilized," Air Canada stated.
Venezuela has been the scene of violent protest for six weeks during which 29 people have been killed.
Since early February, students and hardline opposition leaders have been calling supporters onto the streets to protest against President Nicolas Maduro and his socialist government.
The demonstrators are demanding political change and an end to high inflation, shortages of basic foods and one of the worst rates of violent crime in the world.
The protests, however, show no signs of toppling Maduro, 51, a former bus driver who narrowly won an election in April 2013 to replace his late friend and mentor, Hugo Chavez.
The armed forces seem to be firmly behind Maduro, and the protesters are far fewer than those who took to the streets a decade ago to oust Chavez, albeit briefly.
-- with files from Reuters